The Prasannapada is one of Candrakirti's most important compositions. Of its twenty-seven chapters commenting on Nagarjuna's Mulamadhyamakakarika, the first, which would influence the later course of the Madhyamaka school, is the longest and most wide-ranging. It is here that Candrakirti, in addition to elucidating Nagarjuna's refutation of the real existence of causes and conditions, defends his own views on critical issues of ontology and epistemology against those of prominent Buddhist scholars such as the Madhyamika Bhaviveka and the founder of the logical-epistemological school, i. e., Dignaga, as well as non-Buddhist adversaries such as the Naiyayikas. His detailed defense of the earlier Mulamadhyamakakarika commentator Buddhapalita from Bhaviveka's critique became a topic of intense debate for Tibetan exegetes, and is often pinpointed as the source of the bifurcation of the Madhyamaka school into discrete streams and as holding the key to the controversial Prasangika-Svatantrika distinction.

Of utmost importance for the correct understanding of the philosophical views presented in Candrakirti's works are reliably edited texts of the original Sanskrit. In the century since the publication of Louis de La Vall�e Poussin's edition of the Prasannapada, a number of old Sanskrit manuscripts of the work have been discovered, and Anne MacDonald has harvested their riches for this new edition of its first chapter. Her accompanying copiously annotated English translation makes accessible in all their complexity and brilliance Candrakirti's arguments against his opponents, and significantly enhances our understanding of seminal aspects of his Madhyamaka vision.